Cellular Immunology Tests (Control serum)

Legacy laboratory-loinc serology-non-micro
1

Hi,

I have a question for the group.

My colleague is performing LOINC mapping for a clinical immunology lab at present.

We find that there are dozens of cellular immunology tests related to patient serum mxied with control serum which most likely fail to map a LOINC code.

For example: Natural Killer cell function - Lymphocytes Patient/Control, Target Effector 1:5 Patient/Control, Target Effector 1:10 Patient/Control, Target Effector 1:10 Patient/Control, Target Effector 1:20 Patient/Control, Target Effector 1:40 Patient/Control,Target Effector 1:80 Patient/Control,…

Is there any suggestion?

Say, propose a new LOINC to Regenstrief or create local LOINC for them

Thanks in advance for your comment.



Sincerely,

John

2

These may need to be local codes, but I can respond better if I could see and example report and product insert.

3

Attached with a sample report:-



NK CELL NUMBER & FUNCTION



Specimen: Heparinised and EDTA blood



PATIENT CONTROL NORMAL RANGE(For age)

WBC 7060 /uL 4790 /uL 4500 - 8400

Differential N(25) L(65) M(5) E(1) N(48) L(37) M(7) E(3)

B(1) O(3) B(1) O(4)

Lymphocytes 4582 H /uL 1782 /uL 1500 - 3200

NK cells (CD3-CD16/56+) % 2.0 L % 12.2 % 11 - 24

NK cells (CD3-CD16/56+) no. 93 L /uL 217 /uL 300 - 600



MICROCYTOTOXICITY ASSAY

Target cell : Effector cell NORMAL RANGE(Adult)

1 : 5 0.7 L % 13.3 % 1 - 43

1 : 10 4.6 % 21.0 % 2 - 68

1 : 20 10.4 L % 36.6 % 15 - 78

1 : 40 16.1 L % 48.9 % 23 - 77

1 : 80 21.6 L % 53.9 % 27 - 80



Comment: Low NK cytotoxicity partly due to low NK cell number. Taking this into

consideration the NK cytotoxicity is considered impaired or low normal.

4

We’d like to see a package insert. Can you provide one, or point to a URL for a package insert or reference information. Thanks.