# Soluble Liver vs Cytokeratin - duplicates?

**URL:** <https://forum.loinc.org/t/soluble-liver-vs-cytokeratin-duplicates/648>\
**Category:** serology-non-micro\
**Created:** [February 11, 2009, 5:35pm UTC](https://forum.loinc.org/t/soluble-liver-vs-cytokeratin-duplicates/648 "2009-02-11T17:35:50Z")\
**Posts on this page:** 5\
**Page:** 1

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**Author:** ![pdbanning](https://forum.loinc.org/letter_avatar_proxy/v4/letter/p/9f8e36/32.png) [@pdbanning](https://forum.loinc.org/u/pdbanning)\
**Post date:** [February 11, 2009, 5:35pm UTC](https://forum.loinc.org/t/soluble-liver-vs-cytokeratin-duplicates/648/1 "2009-02-11T17:35:50Z")

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Would like to hear opinions on if the terms Soluble Liver and Cytokerin antibodies are synonymous as a laboratory serology analyte? The following test catalogs indicate they are:  
  
  
  
[http://www.specialtylabs.com/books/print\_view.asp?id=270](http://www.specialtylabs.com/books/print_view.asp?id=270)  
  
[http://www.ucihs.uci.edu/som/pathology/Pathology%20Service%20Manual/SOLUBLE%20LIVER%20ANTIGEN%20ANTIBODY,%20IgG.htm](http://www.ucihs.uci.edu/som/pathology/Pathology%20Service%20Manual/SOLUBLE%20LIVER%20ANTIGEN%20ANTIBODY,%20IgG.htm)  
  
[http://www.floridapathology.com/testdescription.asp?ID=1027](http://www.floridapathology.com/testdescription.asp?ID=1027)  
  
  
  
Thanks for your input!

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**Author:** ![marilyn-stark](https://forum.loinc.org/letter_avatar_proxy/v4/letter/m/bbce88/32.png) [@marilyn-stark](https://forum.loinc.org/u/marilyn-stark)\
**Post date:** [February 11, 2009, 7:33pm UTC](https://forum.loinc.org/t/soluble-liver-vs-cytokeratin-duplicates/648/2 "2009-02-11T19:33:10Z")

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Hi Pam,  
  
We have these in our local RI dictionary as synonyms. There were created as such in 2003 and I’m copying the test description here in case that helps:  
  
Presence of autoantibodies against soluble liver antigens (SLA) which react with liver cytokeratins by EIA method reported as EU-Elisa Units. The presence of SLA antibodies has almost 100% specificity for autoimmune hepatitis, although only 12-30% have these antibodies. Thus, a negative SLA IgG test does not rule out autoimmune hepatitis. Auto Immune Hepatitis (AIH) Type 3 is characterized by the presence of autoantibodies against soluble liver antigens (SLA) which react with liver cytokeratins.  
  
  
  
Marilyn

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**Author:** ![pdbanning](https://forum.loinc.org/letter_avatar_proxy/v4/letter/p/9f8e36/32.png) [@pdbanning](https://forum.loinc.org/u/pdbanning)\
**Post date:** [February 11, 2009, 10:58pm UTC](https://forum.loinc.org/t/soluble-liver-vs-cytokeratin-duplicates/648/3 "2009-02-11T22:58:56Z")

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Hi Marilyn,  
  
  
  
Please check out the following LOINC codes:  
  
12734-0 Cytokeratin Ab:ACnc:Pt:Ser:Qn  
  
13925-3 Cytokeratin Ab:ACnc:Pt:Ser:Ord  
  
  
  
54026-0 Soluble Liver Ab:ACnc:Pt:Ser:Qn  
  
54029-4 Soluble Liver Ab:ACnc:Pt:Ser:Ord  
  
  
  
We believe these are duplicates. Thank you very much for your consideration!

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**Author:** ![kmercer](https://forum.loinc.org/letter_avatar_proxy/v4/letter/k/bb73d2/32.png) [@kmercer](https://forum.loinc.org/u/kmercer)\
**Post date:** [February 12, 2009, 4:28pm UTC](https://forum.loinc.org/t/soluble-liver-vs-cytokeratin-duplicates/648/4 "2009-02-12T16:28:26Z")

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The requester of the 2 Soluble liver Ab codes felt that soluble liver antibodies were not quite the same as cytokeratin antibodies. I am trying to get supporting documentation from them.  
  
… Stay tuned 🙂

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**Author:** ![system](https://forum.loinc.org/uploads/default/original/1X/dbab97ce9b2987d788a376e254fcaae249f3b672.png) [@system](https://forum.loinc.org/u/system)\
**Post date:** [June 23, 2023, 3:36pm UTC](https://forum.loinc.org/t/soluble-liver-vs-cytokeratin-duplicates/648/5 "2023-06-23T15:36:20Z")

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