# IGH gene rearrangement LOINC codes

**URL:** <https://forum.loinc.org/t/igh-gene-rearrangement-loinc-codes/1199>\
**Category:** genetics\
**Created:** [January 31, 2023, 9:58pm UTC](https://forum.loinc.org/t/igh-gene-rearrangement-loinc-codes/1199 "2023-01-31T21:58:58Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![apatel59](https://forum.loinc.org/letter_avatar_proxy/v4/letter/a/db5fbb/32.png) [@apatel59](https://forum.loinc.org/u/apatel59)\
**Post date:** [January 31, 2023, 9:58pm UTC](https://forum.loinc.org/t/igh-gene-rearrangement-loinc-codes/1199/1 "2023-01-31T21:58:58Z")

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Hello,

I have a stakeholder asking how to report IGH gene rearrangement. Presumably, these should be along the lines of the existing IGH gene rearrangement LOINC codes, I have looked at the guide and section 3.9.6.4 Hematopathology gene re-arrangement. I’m not quite sure how to indicate the different regions identified in LOINC

Gene: IGH, Region: FR1-JH, Result: Polyclonal

Gene: IGH, Region: FR2-JH, Result: Polyclonal

Gene: IGH, Region: FR3-JH, Result: Polyclonal

Gene: TCRG, Locus: 7q14, Result: Polyclonal

Anil

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**Author:** ![pdbanning](https://forum.loinc.org/letter_avatar_proxy/v4/letter/p/9f8e36/32.png) [@pdbanning](https://forum.loinc.org/u/pdbanning)\
**Post date:** [September 5, 2023, 5:23pm UTC](https://forum.loinc.org/t/igh-gene-rearrangement-loinc-codes/1199/2 "2023-09-05T17:23:08Z")

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Hello Anil,  
I apologize for not responding sooner. Have you looked at the DNA region of interest panel for components that will help portray the different regions? [LOINC 53041-0 DNA region of interest panel](https://loinc.org/53041-0/)

Maybe Eza and I can add this to September LOINC Lab committee call if you need more assistance.  
Pam

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<div class="post-metadata">

**Author:** ![apatel59](https://forum.loinc.org/letter_avatar_proxy/v4/letter/a/db5fbb/32.png) [@apatel59](https://forum.loinc.org/u/apatel59)\
**Post date:** [September 5, 2023, 6:55pm UTC](https://forum.loinc.org/t/igh-gene-rearrangement-loinc-codes/1199/3 "2023-09-05T18:55:35Z")

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Thank you Pam. We found this link from LabCorp, which has a different set of LOINC Codes for the results, and more IgH focused.

[481222: B-Cell Gene Rearrangements Profile, IgH and IgK | Labcorp](https://www.labcorp.com/tests/481222/b-cell-gene-rearrangements-profile-igh-and-igk) ( IgH Gene Rearrangement Assay)

This could serve as a valuable discussion point in our upcoming meeting, helping us gain insights into the reporting of gene/DNA arrangements of this nature. It appears that, in many laboratories, this information is commonly conveyed through PDFs or text-based blob. However, it’s worth noting that there is a growing trend towards more specific and structured reporting requests.

Anil